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Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia.

Intensive care medicine experimental

Ergin B, Guerci P, Zafrani L, Nocken F, Kandil A, Gurel-Gurevin E, Demirci-Tansel C, Ince C.
PMID: 27671340
Intensive Care Med Exp. 2016 Dec;4(1):29. doi: 10.1186/s40635-016-0106-1. Epub 2016 Sep 26.

BACKGROUND: Modulation of inflammation and oxidative stress appears to limit sepsis-induced damage in experimental models. The kidney is one of the most sensitive organs to injury during septic shock. In this study, we evaluated the effect of N-acetylcysteine (NAC)...

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Ergin B, Guerci P, Zafrani L, et al. Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive Care Med Exp. 2016;4(1):29doi: 10.1186/s40635-016-0106-1.
Ergin, B., Guerci, P., Zafrani, L., Nocken, F., Kandil, A., Gurel-Gurevin, E., Demirci-Tansel, C., & Ince, C. (2016). Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive care medicine experimental, 4(1), 29. https://doi.org/10.1186/s40635-016-0106-1
Ergin, Bulent, et al. "Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia." Intensive care medicine experimental vol. 4,1 (2016): 29. doi: https://doi.org/10.1186/s40635-016-0106-1
Ergin B, Guerci P, Zafrani L, Nocken F, Kandil A, Gurel-Gurevin E, Demirci-Tansel C, Ince C. Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive Care Med Exp. 2016 Dec;4(1):29. doi: 10.1186/s40635-016-0106-1. Epub 2016 Sep 26. PMID: 27671340; PMCID: PMC5037099.
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Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model.

Intensive care medicine experimental

Sperber J, Nyberg A, Lipcsey M, Melhus Å, Larsson A, Sjölin J, Castegren M.
PMID: 28861863
Intensive Care Med Exp. 2017 Aug 31;5(1):40. doi: 10.1186/s40635-017-0152-3.

BACKGROUND: Mechanical ventilation with positive end expiratory pressure and low tidal volume, i.e. protective ventilation, is recommended in patients with acute respiratory distress syndrome. However, the effect of protective ventilation on bacterial growth during early pneumonia in non-injured lungs...

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Sperber J, Nyberg A, Lipcsey M, et al. Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model. Intensive Care Med Exp. 2017;5(1):40doi: 10.1186/s40635-017-0152-3.
Sperber, J., Nyberg, A., Lipcsey, M., Melhus, �. �., Larsson, A., Sjölin, J., & Castegren, M. (2017). Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model. Intensive care medicine experimental, 5(1), 40. https://doi.org/10.1186/s40635-017-0152-3
Sperber, Jesper, et al. "Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model." Intensive care medicine experimental vol. 5,1 (2017): 40. doi: https://doi.org/10.1186/s40635-017-0152-3
Sperber J, Nyberg A, Lipcsey M, Melhus Å, Larsson A, Sjölin J, Castegren M. Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model. Intensive Care Med Exp. 2017 Aug 31;5(1):40. doi: 10.1186/s40635-017-0152-3. PMID: 28861863; PMCID: PMC5578946.
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The metabolic phenotype of rodent sepsis: cause for concern?.

Intensive care medicine experimental

Zolfaghari PS, Pinto BB, Dyson A, Singer M.
PMID: 26266794
Intensive Care Med Exp. 2013 Dec;1(1):25. doi: 10.1186/2197-425X-1-6. Epub 2013 Oct 29.

PURPOSE: Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies. However, preclinical efficacy in these models has failed to translate to the clinical setting. We thus questioned the representativeness of such...

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Zolfaghari PS, Pinto BB, Dyson A, et al. The metabolic phenotype of rodent sepsis: cause for concern?. Intensive Care Med Exp. 2013;1(1):25doi: 10.1186/2197-425X-1-6.
Zolfaghari, P. S., Pinto, B. B., Dyson, A., & Singer, M. (2013). The metabolic phenotype of rodent sepsis: cause for concern?. Intensive care medicine experimental, 1(1), 25. https://doi.org/10.1186/2197-425X-1-6
Zolfaghari, Parjam S, et al. "The metabolic phenotype of rodent sepsis: cause for concern?." Intensive care medicine experimental vol. 1,1 (2013): 25. doi: https://doi.org/10.1186/2197-425X-1-6
Zolfaghari PS, Pinto BB, Dyson A, Singer M. The metabolic phenotype of rodent sepsis: cause for concern?. Intensive Care Med Exp. 2013 Dec;1(1):25. doi: 10.1186/2197-425X-1-6. Epub 2013 Oct 29. PMID: 26266794; PMCID: PMC4797805.
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Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine.

Intensive care medicine experimental

Cain DJ, Del Arroyo AG, Ackland GL.
PMID: 26266907
Intensive Care Med Exp. 2014 Dec;2(1):6. doi: 10.1186/2197-425X-2-6. Epub 2014 Feb 27.

BACKGROUND: The design of clinical immunology studies in sepsis presents several fundamental challenges to improving the translational understanding of pathologic mechanisms. We undertook a systematic review of bed-to-benchside studies to test the hypothesis that variable clinical design methodologies used...

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Cain DJ, Del Arroyo AG, Ackland GL. Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine. Intensive Care Med Exp. 2014;2(1):6doi: 10.1186/2197-425X-2-6.
Cain, D. J., Del Arroyo, A. G., & Ackland, G. L. (2014). Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine. Intensive care medicine experimental, 2(1), 6. https://doi.org/10.1186/2197-425X-2-6
Cain, David J, et al. "Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine." Intensive care medicine experimental vol. 2,1 (2014): 6. doi: https://doi.org/10.1186/2197-425X-2-6
Cain DJ, Del Arroyo AG, Ackland GL. Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine. Intensive Care Med Exp. 2014 Dec;2(1):6. doi: 10.1186/2197-425X-2-6. Epub 2014 Feb 27. PMID: 26266907; PMCID: PMC4513024.
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The effect of vitamin C on plasma volume in the early stage of sepsis in the rat.

Intensive care medicine experimental

Bark BP, Grände PO.
PMID: 26266908
Intensive Care Med Exp. 2014 Dec;2(1):11. doi: 10.1186/2197-425X-2-11. Epub 2014 Mar 06.

BACKGROUND: Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary leakage of plasma markers. It has still not been investigated,...

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Bark BP, Grände PO. The effect of vitamin C on plasma volume in the early stage of sepsis in the rat. Intensive Care Med Exp. 2014;2(1):11doi: 10.1186/2197-425X-2-11.
Bark, B. P., & Grände, P. O. (2014). The effect of vitamin C on plasma volume in the early stage of sepsis in the rat. Intensive care medicine experimental, 2(1), 11. https://doi.org/10.1186/2197-425X-2-11
Bark, Björn P, and Grände, Per-Olof. "The effect of vitamin C on plasma volume in the early stage of sepsis in the rat." Intensive care medicine experimental vol. 2,1 (2014): 11. doi: https://doi.org/10.1186/2197-425X-2-11
Bark BP, Grände PO. The effect of vitamin C on plasma volume in the early stage of sepsis in the rat. Intensive Care Med Exp. 2014 Dec;2(1):11. doi: 10.1186/2197-425X-2-11. Epub 2014 Mar 06. PMID: 26266908; PMCID: PMC4512993.
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The renal compartment: a hydraulic view.

Intensive care medicine experimental

Cruces P, Salas C, Lillo P, Salomon T, Lillo F, Hurtado DE.
PMID: 26266923
Intensive Care Med Exp. 2014 Dec;2(1):26. doi: 10.1186/s40635-014-0026-x. Epub 2014 Oct 23.

BACKGROUND: The hydraulic behavior of the renal compartment is poorly understood. In particular, the role of the renal capsule on the intrarenal pressure has not been thoroughly addressed to date. We hypothesized that pressure and volume in the renal...

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Cruces P, Salas C, Lillo P, et al. The renal compartment: a hydraulic view. Intensive Care Med Exp. 2014;2(1):26doi: 10.1186/s40635-014-0026-x.
Cruces, P., Salas, C., Lillo, P., Salomon, T., Lillo, F., & Hurtado, D. E. (2014). The renal compartment: a hydraulic view. Intensive care medicine experimental, 2(1), 26. https://doi.org/10.1186/s40635-014-0026-x
Cruces, Pablo, et al. "The renal compartment: a hydraulic view." Intensive care medicine experimental vol. 2,1 (2014): 26. doi: https://doi.org/10.1186/s40635-014-0026-x
Cruces P, Salas C, Lillo P, Salomon T, Lillo F, Hurtado DE. The renal compartment: a hydraulic view. Intensive Care Med Exp. 2014 Dec;2(1):26. doi: 10.1186/s40635-014-0026-x. Epub 2014 Oct 23. PMID: 26266923; PMCID: PMC4512983.
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Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage.

Intensive care medicine experimental

Marbacher S, Neuschmelting V, Andereggen L, Widmer HR, von Gunten M, Takala J, Jakob SM, Fandino J.
PMID: 26266927
Intensive Care Med Exp. 2014 Dec;2(1):30. doi: 10.1186/s40635-014-0030-1. Epub 2014 Nov 30.

BACKGROUND: It is unclear how complex pathophysiological mechanisms that result in early brain injury (EBI) after subarachnoid hemorrhage (SAH) are triggered. We investigate how peak intracranial pressure (ICP), amount of subarachnoid blood, and hyperacute depletion of cerebral perfusion pressure...

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Marbacher S, Neuschmelting V, Andereggen L, et al. Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive Care Med Exp. 2014;2(1):30doi: 10.1186/s40635-014-0030-1.
Marbacher, S., Neuschmelting, V., Andereggen, L., Widmer, H. R., von Gunten, M., Takala, J., Jakob, S. M., & Fandino, J. (2014). Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive care medicine experimental, 2(1), 30. https://doi.org/10.1186/s40635-014-0030-1
Marbacher, Serge, et al. "Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage." Intensive care medicine experimental vol. 2,1 (2014): 30. doi: https://doi.org/10.1186/s40635-014-0030-1
Marbacher S, Neuschmelting V, Andereggen L, Widmer HR, von Gunten M, Takala J, Jakob SM, Fandino J. Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive Care Med Exp. 2014 Dec;2(1):30. doi: 10.1186/s40635-014-0030-1. Epub 2014 Nov 30. PMID: 26266927; PMCID: PMC4512974.
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Validation of computed tomography for measuring lung weight.

Intensive care medicine experimental

Protti A, Iapichino GE, Milesi M, Melis V, Pugni P, Comini B, Cressoni M, Gattinoni L.
PMID: 26266928
Intensive Care Med Exp. 2014 Dec;2(1):31. doi: 10.1186/s40635-014-0031-0. Epub 2014 Dec 05.

BACKGROUND: Lung weight characterises severity of pulmonary oedema and predicts response to mechanical ventilation. The aim of this study was to evaluate the accuracy of quantitative analysis of thorax computed tomography (CT) for measuring lung weight in pigs with...

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Protti A, Iapichino GE, Milesi M, et al. Validation of computed tomography for measuring lung weight. Intensive Care Med Exp. 2014;2(1):31doi: 10.1186/s40635-014-0031-0.
Protti, A., Iapichino, G. E., Milesi, M., Melis, V., Pugni, P., Comini, B., Cressoni, M., & Gattinoni, L. (2014). Validation of computed tomography for measuring lung weight. Intensive care medicine experimental, 2(1), 31. https://doi.org/10.1186/s40635-014-0031-0
Protti, Alessandro, et al. "Validation of computed tomography for measuring lung weight." Intensive care medicine experimental vol. 2,1 (2014): 31. doi: https://doi.org/10.1186/s40635-014-0031-0
Protti A, Iapichino GE, Milesi M, Melis V, Pugni P, Comini B, Cressoni M, Gattinoni L. Validation of computed tomography for measuring lung weight. Intensive Care Med Exp. 2014 Dec;2(1):31. doi: 10.1186/s40635-014-0031-0. Epub 2014 Dec 05. PMID: 26266928; PMCID: PMC4512984.
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Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.

Intensive care medicine experimental

Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ.
PMID: 29058092
Intensive Care Med Exp. 2017 Oct 23;5(1):48. doi: 10.1186/s40635-017-0159-9.

BACKGROUND: Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxin-associated shock is unknown.METHODS: We therefore tested AIG in sedated, mechanically ventilated...

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Suffredini DA, Cui X, Jaswal D, et al. Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. Intensive Care Med Exp. 2017;5(1):48doi: 10.1186/s40635-017-0159-9.
Suffredini, D. A., Cui, X., Jaswal, D., Remy, K. E., Li, Y., Sun, J., Solomon, S. B., Fitz, Y., Moayeri, M., Leppla, S., & Eichacker, P. Q. (2017). Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. Intensive care medicine experimental, 5(1), 48. https://doi.org/10.1186/s40635-017-0159-9
Suffredini, Dante A, et al. "Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support." Intensive care medicine experimental vol. 5,1 (2017): 48. doi: https://doi.org/10.1186/s40635-017-0159-9
Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ. Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support. Intensive Care Med Exp. 2017 Oct 23;5(1):48. doi: 10.1186/s40635-017-0159-9. PMID: 29058092; PMCID: PMC5651533.
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Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema.

Intensive care medicine experimental

Padilha GA, Horta LF, Moraes L, Braga CL, Oliveira MV, Santos CL, Ramos IP, Morales MM, Capelozzi VL, Goldenberg RC, de Abreu MG, Pelosi P, Silva PL, Rocco PR.
PMID: 27761886
Intensive Care Med Exp. 2016 Dec;4(1):35. doi: 10.1186/s40635-016-0107-0. Epub 2016 Oct 19.

BACKGROUND: In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort and providing adequate gas exchange. We evaluated the impact of pressure-controlled ventilation (PCV) and pressure support ventilation (PSV) on pulmonary...

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Padilha GA, Horta LF, Moraes L, et al. Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema. Intensive Care Med Exp. 2016;4(1):35doi: 10.1186/s40635-016-0107-0.
Padilha, G. A., Horta, L. F., Moraes, L., Braga, C. L., Oliveira, M. V., Santos, C. L., Ramos, I. P., Morales, M. M., Capelozzi, V. L., Goldenberg, R. C., de Abreu, M. G., Pelosi, P., Silva, P. L., & Rocco, P. R. (2016). Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema. Intensive care medicine experimental, 4(1), 35. https://doi.org/10.1186/s40635-016-0107-0
Padilha, Gisele de A, et al. "Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema." Intensive care medicine experimental vol. 4,1 (2016): 35. doi: https://doi.org/10.1186/s40635-016-0107-0
Padilha GA, Horta LF, Moraes L, Braga CL, Oliveira MV, Santos CL, Ramos IP, Morales MM, Capelozzi VL, Goldenberg RC, de Abreu MG, Pelosi P, Silva PL, Rocco PR. Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema. Intensive Care Med Exp. 2016 Dec;4(1):35. doi: 10.1186/s40635-016-0107-0. Epub 2016 Oct 19. PMID: 27761886; PMCID: PMC5071308.
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Erratum to: Heparin-binding protein is important for vascular leak in sepsis.

Intensive care medicine experimental

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A.
PMID: 28108970
Intensive Care Med Exp. 2017 Dec;5(1):6. doi: 10.1186/s40635-017-0119-4. Epub 2017 Jan 20.

No abstract available.

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Bentzer P, Fisher J, Kong HJ, et al. Erratum to: Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp. 2017;5(1):6doi: 10.1186/s40635-017-0119-4.
Bentzer, P., Fisher, J., Kong, H. J., Mörgelin, M., Boyd, J. H., Walley, K. R., Russell, J. A., & Linder, A. (2017). Erratum to: Heparin-binding protein is important for vascular leak in sepsis. Intensive care medicine experimental, 5(1), 6. https://doi.org/10.1186/s40635-017-0119-4
Bentzer, Peter, et al. "Erratum to: Heparin-binding protein is important for vascular leak in sepsis." Intensive care medicine experimental vol. 5,1 (2017): 6. doi: https://doi.org/10.1186/s40635-017-0119-4
Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A. Erratum to: Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp. 2017 Dec;5(1):6. doi: 10.1186/s40635-017-0119-4. Epub 2017 Jan 20. PMID: 28108970; PMCID: PMC5250623.
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Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis.

Intensive care medicine experimental

Jeger V, Arrigo M, Hildenbrand FF, Müller D, Jirkof P, Hauffe T, Seifert B, Arras M, Spahn DR, Bettex D, Rudiger A.
PMID: 28429311
Intensive Care Med Exp. 2017 Dec;5(1):23. doi: 10.1186/s40635-017-0137-2. Epub 2017 Apr 20.

BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle....

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Jeger V, Arrigo M, Hildenbrand FF, et al. Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis. Intensive Care Med Exp. 2017;5(1):23doi: 10.1186/s40635-017-0137-2.
Jeger, V., Arrigo, M., Hildenbrand, F. F., Müller, D., Jirkof, P., Hauffe, T., Seifert, B., Arras, M., Spahn, D. R., Bettex, D., & Rudiger, A. (2017). Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis. Intensive care medicine experimental, 5(1), 23. https://doi.org/10.1186/s40635-017-0137-2
Jeger, Victor, et al. "Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis." Intensive care medicine experimental vol. 5,1 (2017): 23. doi: https://doi.org/10.1186/s40635-017-0137-2
Jeger V, Arrigo M, Hildenbrand FF, Müller D, Jirkof P, Hauffe T, Seifert B, Arras M, Spahn DR, Bettex D, Rudiger A. Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis. Intensive Care Med Exp. 2017 Dec;5(1):23. doi: 10.1186/s40635-017-0137-2. Epub 2017 Apr 20. PMID: 28429311; PMCID: PMC5399012.
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Showing 1 to 12 of 440 entries